Last edited by Dokinos
Thursday, April 16, 2020 | History

4 edition of Use of epoetin for anemia in chronic renal failure found in the catalog.

Use of epoetin for anemia in chronic renal failure

Use of epoetin for anemia in chronic renal failure

  • 308 Want to read
  • 0 Currently reading

Published by Agency for Healthcare Research and Quality in [Rockville, Md .
Written in English

    Subjects:
  • Recombinant erythropoietin -- Therapeutic use,
  • Anemia -- Chemotherapy,
  • Chronic renal failure -- Complications -- Chemotherapy

  • Edition Notes

    SeriesEvidence report/technology assessment -- no. 29, AHRQ publication -- no. 01-E 015
    ContributionsUnited States. Agency for Healthcare Research and Quality
    The Physical Object
    FormatElectronic resource
    ID Numbers
    Open LibraryOL14541814M
    OCLC/WorldCa55089389

    The active substance in Epoetin Alfa Hexal, epoetin alfa, is a copy of a hormone called erythropoietin, and works in exactly the same way as the natural hormone to stimulate the production of red blood cells in the bone marrow. Erythropoietin is produced by the kidneys. In patients receiving chemotherapy or with kidney problems, anaemia can be caused by a lack of erythropoietin, or by the body. Epoetin alfa is a human erythropoietin produced in cell culture using recombinant DNA technology. Authorised by the European Medicines Agency on 28 August , it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat anemia, commonly associated with chronic kidney failure and cancer status: AU: S4 (Prescription only), US: ℞-only. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.


Share this book
You might also like
cruise of the Susan.

cruise of the Susan.

Off-farm income and employment characteristics of Nebraskas farm families

Off-farm income and employment characteristics of Nebraskas farm families

Destined for an early grave

Destined for an early grave

Intimacies & intrigues

Intimacies & intrigues

International Council on Archives

International Council on Archives

Data report for 1980-1981 seismic-refraction profiles in the western Mojave Desert, California

Data report for 1980-1981 seismic-refraction profiles in the western Mojave Desert, California

Winning isnt everything

Winning isnt everything

The Mitchell Beazley pocket guide to aquarium fishes.

The Mitchell Beazley pocket guide to aquarium fishes.

Study of marketing strategy of Daewoo Motor Company Ltd. within the U.K. car market.

Study of marketing strategy of Daewoo Motor Company Ltd. within the U.K. car market.

Selection of management personnel.

Selection of management personnel.

The National League

The National League

Equilibrium price distributions and the economics of information

Equilibrium price distributions and the economics of information

Developing academic literacy

Developing academic literacy

Principles of home inspection

Principles of home inspection

Chesapeake & Ohio Canal National Historical Park, Williamsport, Maryland, milepost 98.96-99.85

Chesapeake & Ohio Canal National Historical Park, Williamsport, Maryland, milepost 98.96-99.85

Blind wisdom

Blind wisdom

Neverness.

Neverness.

Canada-United States Interparliamentary Group

Canada-United States Interparliamentary Group

Use of epoetin for anemia in chronic renal failure Download PDF EPUB FB2

29 Use of Epoetin for Anemia in Chronic Renal Failure: Summary CR Flamm, N Aronson, R Bohn, B Finkelstein, M Piper, J Seidenfeld, CJ Bonnell, M Carter, M Gere, and KM Ziegler. Current as of August Author: CR Flamm, N Aronson, R Bohn, B Finkelstein, M Piper, J Seidenfeld, CJ Bonnell, M Carter, M Gere, KM.

EPOGEN ® (epoetin alfa) is indicated for the treatment of anemia due to chronic kidney disease (CKD) in patients on dialysis to decrease the need for red blood cell (RBC) transfusion. Limitations of Use: Aranesp ® and EPOGEN ® have not been shown to.

Use: Treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy. Usual Adult Dose for Anemia Associated with Chronic Renal Failure. Chronic Kidney Disease (CKD) Patients Not on Dialysis: Initial dose: 50 to units/kg IV or subcutaneously 3 times a week Comments/ Download Citation | Use of Epoetin in Chronic Renal Failure | In this issue of JAMA, Thamer and colleagues1 examine the use of epoetin in US dialysis facilities.

This report comes at an opportune. Symptomatic anemia is a common complication of chronic renal failure. Treatment is now possible with the availability of recombinant human erythropoietin (epoetin alfa). Previous experimental studies have suggested that correcting the anemia of chronic renal failure may be harmful in that renal failure Cited by: Study suggests use of erythropoietin along with iron for treatment of renal failure associated anemia is more beneficial for CKD patients having low Hb.

Also study conclude the use of lower than normal dose (– IU) of ESA is appropriate when hemoglobin reaches 11 g/dl in hemodialysis by: 3. This protein may be reduced when you have kidney failure or use certain medications.

When fewer red blood cells are produced, you can develop a condition called anemia. Epoetin alfa is used to treat anemia caused by chemotherapy or chronic kidney disease, or anemia caused by taking zidovudine to treat HIV (human immunodeficiency virus)/ New approaches to the management of anemia of chronic kidney disease: Beyond Epogen and Infed A Rastogi1 and AR Nissenson2 1Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA and 2Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

EPOGEN® (epoetin alfa) is used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease in patients on dialysis to reduce or.

EPOGEN ® is indicated for the treatment of anemia due to chronic kidney disease (CKD) in patients on dialysis to decrease the need for red blood cell (RBC) transfusion.

EPOGEN ® is not indicated for use as a substitute for RBC transfusions in patients who require immediate correction of anemia. Erythropoietin deficiency is an important cause of chronic kidney disease (CKD) anemia in both adults and children.

Erythropoietin treatment has transformed the lives of millions of CKD patients. Several forms of recombinant erythropoietin are currently available, and treatment is by: 1. Use of epoetin for anemia in chronic renal failure: Redding Flamm C, Aronson N, Bohn R, Finkelstein B, Piper M, Seidenfeld J, Bonnell C J, Carter M, Gere M, Ziegler K M Authors' objectives.

The primary objective was to assess the outcomes of maintaining target haematocrit (Hct) levels at greater than 36%, compared with maintenance at 33 to 36%. Get this from a library. Use of epoetin for anemia in chronic renal failure. [Carole Redding Flamm; Blue Cross and Blue Shield Association.

Technology Evaluation Center.; United States. Agency for Healthcare Research and Quality.;]. ANEMIA IN CHRONIC RENAL FAILURE. Anemia occurs in many patients with chronic renal failure (CRF), and the severity and progression of anemia often correlates with the degree of CRF.

However, it is important to keep in mind that anemia may be exacerbated by things other than CRF, such as concurrent diseases or by iatrogenic blood loss associated with repeated sampling of blood for. INDICATIONS AND USAGE Treatment of Anemia of Chronic Renal Failure Patients EPOGEN® is indicated for the treatment of anemia associated with CRF, including patients on dialysis and patients not on dialysis.

EPOGEN® is indicated to elevate or maintain the red blood cell level (as manifested by the hematocrit or hemoglobin determinations) and to decrease the need for transfusions. Background: Anemia is present in 30–65% in cats with chronic kidney disease (CKD) and few long-term treatment options exist.

Darbepoetin is effective in treating anemia of kidney disease in humans and may be used in cats. Hypothesis/Objective: To evaluate the use of darbepoetin, a recombinant analog of human erythropoietin, to stimulate Cited by: Epogen, Procrit, Retacrit.

Treatment of anemia in patients with nonmyeloid malignancies where anemia is due to effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of 2 additional months of planned chemotherapy. The outcomes for patients with anemia of renal disease are guarded.

Many develop adverse cardiac events that lead to a high mortality rate. Too much iron from blood transfusions also affects outcomes. Finally, chronic use of erythropoietin has been associated with severe hypertension, stroke and heart failure. Recombinant human erythropoietin (r-HuEPO) therapy for anemia in chronic renal failure patients could have unfavorable renal effects since reversal of anemia can raise blood pressure and accelerate experimental glomerular by: PROCRIT ® is indicated for the treatment of anemia due to chronic kidney disease (CKD),including patients on dialysis and not on dialysis, to decrease the need for red blood cell (RBC) transfusion.

In controlled trials, patients with chronic kidney disease (CKD) such as renal impairment or renal failure experienced greater risks for mortality, myocardial infarction, congestive heart failure, thromboembolism, and stroke when administered epoetin alfa and other erythropoiesis-stimulating agents (ESAs) to a target hemoglobin concentration greater than 11 g/dL.

CHRONIC renal failure almost invariably results in anemia. Suggested contributors to this anemia include a relative or absolute deficiency of erythropoietin,1, 2 decreased survival of red cells,3 Cited by: Anemia commonly occurs in people with chronic kidney disease (CKD)—the permanent, partial loss of kidney function.

Anemia might begin to develop in the early stages of CKD, when someone has 20 to 50 percent of normal kidney function. Anemia tends to worsen as CKD progresses. Most people who have total loss of kidney function, or kidney.

improve-patient reported outcomes in patients with chronic kidney disease. Many studies have been conducted over the past 20 years evaluating different dosing regimens of epoetin alfa.

These studies have demonstrated the efficacy of epoetin alfa in the treatment of anemia in chronic kidney Size: 1MB. PROCRIT® is a man-made form of erythropoietin that causes your bone marrow to make more red blood cells helping to fight anemia. This raises the hemoglobin level and may reduce the need for a blood transfusion for patients with Chronic Kidney Disease (CKD).

There are many different types of side effects that can occur with PROCRIT®. Using PROCRIT® can lead to death or other serious side.

Anemia in the setting of chronic kidney disease is a well-recognized phenomenon that is associated with decreasing renal function and deficiency of or resistance to erythropoietin. Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia T.B. Drüeke and Others; Original Article Correction of Anemia with Epoetin Alfa in Chronic Kidney.

Erythropoietin in chronic renal failure Principal discussant: FERNANDO VALDERRABANO Hospital General Universitario Gregorio MarañOn, Madrid, Spain A year-old man was admitted to the Nephrology Department at the Hospital General Universitario Gregorio Marafión because of progressive renal failure, severe anemia, and intense fatigue.

Current use of recombinant human erythropoietin (EPO) to ameliorate the anemia in patients with chronic renal disease has been spectacularly successful and has shown that the primary cause of the anemia found in almost all patients with renal failure is due to a.

Since the introduction of recombinant human erythropoietin (rHuEPO, epoetin) inhealthcare providers have had an effective tool for anemia management in patients with chronic kidney disease (CKD), both before renal replacement therapy becomes necessary and after the onset of end-stage renal disease (ESRD).

Blood transfusions using healthy, erythropoietin-rich blood may help treat some forms of anemia from chronic kidney failure. Sometimes, however, a blood transfusion is not possible.

Epoetin alfa is a man-made, injectable drug for treating anemia associated with chronic kidney failure for people who are or will be receiving n alfa is also used to treat anemia in individuals with HIV infection and in patients with cancer who are receiving chemotherapy.

Erythropoietin is a protein that normally is made in the body by the kidney. Although epoetin alfa therapy does not appear to have direct vasopressor effects, blood pressure may rise during therapy, especially during the early phase of treatment, when the Hb is rising.

In patients with chronic kidney disease who require correction for severe anemia, epoetin alfa therapy should not be used as a replacement for transfusion. Anemia in chronic kidney disease (CKD) has been recognized as a separate independent risk factor of cardiovascular (CV) events.

The aim of the review is to provide a literature summary concerning early diagnosis and treatment of anemia in CKD that may be useful for clinicians and contribute to decrease CV mortality. Literature searches were made in such major databases as: Author: Yuriy S. Milovanov, Lidia V.

Lysenko, Ludmila nova, Victor Fomin, Nikolay A. Mukhin, Elena I. Three randomized outcome trials (Normal Hematocrit Study [NHS], Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease [CHOIR], and Trial of Darbepoetin Alfa in Type 2 Diabetes and CKD [TREAT]) have been conducted in patients with CKD using Epogen/PROCRIT/Aranesp to target higher vs.

lower hemoglobin levels. MONDAY, Feb. 15, (HealthDay News) -- The pricey anemia drugs often given to people with chronic kidney disease may make no difference in how they feel day to day, a new research review confirms.

Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. ;(20)– PubMed CrossRef Google ScholarAuthor: Larry A. Greenbaum. Stages of Chronic Kidney disease There are five stages of chronic kidney disease.

They are shown in the table below. Your doctor deter-mines your stage of kidney disease based on the presence of kidney damage and your glomerular filtra-tion rate (GFR), which is a measure of your level of kidney function.

Your treatment is based on yourFile Size: KB. New data show that the way Procrit, Epogen, and Aranesp are used in patients with chronic kidney disease puts them at risk of heart attacks, stroke, Author: Daniel J. Denoon. Erythropoietin, commonly known by the brand names of Epogen® or Procrit®, is a synthetic form of the naturally occurring hormone normally produced in the kidney.

It is used in dogs and cats to treat anemia that occurs secondary to kidney failure. Erythropoietin stimulates the production of red blood cells (red corpuscles). The purpose of this study is to show that giving PROCRIT (Epoetin alfa) every 2 weeks to increase the hemoglobin (Hb) level and then to adjust the PROCRIT (Epoetin alfa) dose every 4 weeks (Q4W) to maintain Hb levels, is safe and effective in patients with anemia from Chronic Kidney Disease (CKD), not on dialysis, who reside in long-term care facilities.Congestive Heart Failure and Chronic Kidney Disease-associated Anemia Despite its high prevalence and attendant adverse consequences, CHF-associated anemia may be under-appreciated.

Twenty-two per cent of patients in the large Studies of Left Ventricular Dysfunction (SOLVD) trial were anemic; anemia severity was linearly associated with.Chronic Renal Failure and Erythropoietin (EPO) Erythropoietin (EPO) is a hormone mainly made by the kidneys and tells stem cells in the bone marrow to make more red blood cells.

In chronic renal failure, less erythropoietin is produced so that patients are more likely to have fatigue and anemia.